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Practical Total Synthesis of the Anti-Influenza Drug GS-4104

✍ Scribed by Rohloff, John C.; Kent, Kenneth M.; Postich, Michael J.; Becker, Mark W.; Chapman, Harlan H.; Kelly, Daphne E.; Lew, Willard; Louie, Michael S.; McGee, Lawrence R.; Prisbe, Ernest J.; Schultze, Lisa M.; Yu, Richard H.; Zhang, Lijun


Book ID
125517492
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
78 KB
Volume
63
Category
Article
ISSN
0022-3263

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Practical synthesis of the anti-HIV drug
✍ Lisa M. Schultze; Harlan H. Chapman; Nathan J.P. Dubree; Robert J. Jones; Kennet πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 216 KB

The anti-HIV nucleotide analogue PMPA can be prepared on a kilogram-scale by a three step sequence: i) condensation of adenine with (R)-propylene carbonate, ii) alkylation of the resulting (R)-9-(2-hydroxypropyl)adenine with diethyl p-toluenesulfonyloxymethanephosphonate using lithium tert-butoxide