Practical synthesis of the anti-HIV drug, PMPA

✍ Scribed by Lisa M. Schultze; Harlan H. Chapman; Nathan J.P. Dubree; Robert J. Jones; Kenneth M. Kent; Thomas T. Lee; Michael S. Louie; Michael J. Postich; Ernest J. Prisbe; John C. Rohloff; Richard H. Yu

• Book ID: 104258912
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 216 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)00131-2

✦ Synopsis

The anti-HIV nucleotide analogue PMPA can be prepared on a kilogram-scale by a three step sequence: i) condensation of adenine with (R)-propylene carbonate, ii) alkylation of the resulting (R)-9-(2-hydroxypropyl)adenine with diethyl p-toluenesulfonyloxymethanephosphonate using lithium tert-butoxide and iii) cleavage of the phosphonate ester functionalities with hromotrimethylsilane,