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Practical Preparation and Resolution of 1-(2‘-Diphenylphosphino-1‘-naphthyl)isoquinoline: A Useful Ligand for Catalytic Asymmetric Synthesis

✍ Scribed by Lim, Chung Woo; Tissot, Olivier; Mattison, Andrew; Hooper, Mark W.; Brown, John M.; Cowley, Andrew R.; Hulmes, David I.; Blacker, A. John


Book ID
126277125
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
97 KB
Volume
7
Category
Article
ISSN
1083-6160

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Synthesis of 4-(2-diphenylphosphino-1-na
✍ V Gautheron Chapoulaud; J Audoux; N Plé; A Turck; G Quéguiner 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 168 KB

We describe a multistep synthesis leading in a good yield to the title compound. The biaryl linkage was formed in a Pd-catalysed coupling of 2-phenyl-4-chloroquinazoline with 2-methoxy-l-naphthylboronic acid. A further metal-catalysed reaction gave the formation of the naphthylphosphorus bond allowi