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Synthesis of 4-(2-diphenylphosphino-1-naphthyl)-2-phenylquinazoline; a potential PN chelating ligand for asymmetric catalysis

✍ Scribed by V Gautheron Chapoulaud; J Audoux; N Plé; A Turck; G Quéguiner

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 168 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01648-2

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✦ Synopsis

We describe a multistep synthesis leading in a good yield to the title compound. The biaryl linkage was formed in a Pd-catalysed coupling of 2-phenyl-4-chloroquinazoline with 2-methoxy-l-naphthylboronic acid. A further metal-catalysed reaction gave the formation of the naphthylphosphorus bond allowing us to obtain the required phosphonimine ligand 1 as the racemate.

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