## Abstract The asymmetric synthesis of (+)โ(11__R__,12__S__)โmefloquine hydrochloride, an antimalarial drug, was accomplished from commercially available 2โtrifluoromethylaniline, ethyl 4,4,4โtrifluoroacetoacetate and cyclopentanone in 7 steps with a 14% overall yield. The key steps were prolineโc
Practical Asymmetric Synthesis of (+)-erythro Mefloquine Hydrochloride
โ Scribed by Hems, William P.; Jackson, William P.; Nightingale, Peter; Bryant, Rob
- Book ID
- 111918066
- Publisher
- American Chemical Society
- Year
- 2012
- Tongue
- English
- Weight
- 240 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1083-6160
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๐ SIMILAR VOLUMES
D-erythro-Sphingosine 9 is a building block of cerebrosides and glycosphingolipids and was synthesized in 5 steps via an asymmetric aldol addition of the lithiated bislactim ether of cyclo-(L-Val-Gly) 4 to (2E)-hexadecenal(3) in an overall yield of 21 %. I.
erythro-Hydroxyasparagine (eHyAsn, 1) occurs in a number of naturally occurring peptides and proteins. Previous syntheses have relied on enzyme-catalyzed reactions to produce relevant, optically active intermediates. We report herein a completely chemical synthesis that intercepts Boger's synthesis