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Asymmetric synthesis of D-erythro-sphingosine

✍ Scribed by Ulrich Groth; Ulrich Schöllkopf; Thomas Tiller

Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
511 KB
Volume
47
Category
Article
ISSN
0040-4020

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✦ Synopsis

D-erythro-Sphingosine 9 is a building block of cerebrosides and glycosphingolipids and was synthesized in 5 steps via an asymmetric aldol addition of the lithiated bislactim ether of cyclo-(L-Val-Gly) 4 to (2E)-hexadecenal(3) in an overall yield of 21 %. I.

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