𝔖 Bobbio Scriptorium
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Practical access to the proline analogs (S,S,S)- and (R,R,R)-2-methyloctahydroindole-2-carboxylic acids by HPLC enantioseparation

✍ Scribed by Francisco J. Sayago; María J. Pueyo; M. Isabel Calaza; Ana I. Jiménez; Carlos Cativiela


Book ID
102074633
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
168 KB
Volume
23
Category
Article
ISSN
0899-0042

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✍ Marie-Priscille Brun; Anne-Sophie Martin; Christiane Garbay; Laurent Bischoff 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 224 KB

The synthesis of (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid was achieved in two steps, with an overall yield of 53%. This synthesis used Cbz-Glu-OBzl as the starting material and led to the titled compound with a d.e.>96%.