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An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid

✍ Scribed by Marie-Priscille Brun; Anne-Sophie Martin; Christiane Garbay; Laurent Bischoff

Book ID: 104254357
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 224 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01792-1

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✦ Synopsis

The synthesis of (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid was achieved in two steps, with an overall yield of 53%. This synthesis used Cbz-Glu-OBzl as the starting material and led to the titled compound with a d.e.>96%.

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