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An Alternative Route to the Proline Derivative (2S,5R)-5-Ethoxycarbonylmethyl-pyrrolidine-2-carboxylic Acid from Protected Glutamic Acid.

✍ Scribed by Marie-Priscille Brun; Anne-Sophie Martin; Christiane Garbay; Laurent Bischoff

Book ID: 101957383
Publisher: John Wiley and Sons
Year: 2003
Weight: 100 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200352197

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📜 SIMILAR VOLUMES

An alternative route to the proline deri

An alternative route to the proline derivative (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid from protected glutamic acid

✍ Marie-Priscille Brun; Anne-Sophie Martin; Christiane Garbay; Laurent Bischoff 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 224 KB

The synthesis of (2S,5R)-5-ethoxycarbonylmethyl-pyrrolidine-2-carboxylic acid was achieved in two steps, with an overall yield of 53%. This synthesis used Cbz-Glu-OBzl as the starting material and led to the titled compound with a d.e.>96%.

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