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PPARα is a key regulator of hepatic FGF21

✍ Scribed by Thomas Lundåsen; Mary C. Hunt; Lisa-Mari Nilsson; Sabyasachi Sanyal; Bo Angelin; Stefan E.H. Alexson; Mats Rudling

Book ID
116295218
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
312 KB
Volume
360
Category
Article
ISSN
0006-291X

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✍ Cecilia Gälman; Tomas Lundåsen; Alexei Kharitonenkov; Holly A. Bina; Mats Erikss 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 454 KB

FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. However, the physiological role of FGF21 in man is not yet defined and was investigated in our study. Serum FGF21 varied 250-fold among 76 healthy individuals and did not relate to