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The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man

✍ Scribed by Cecilia Gälman; Tomas Lundåsen; Alexei Kharitonenkov; Holly A. Bina; Mats Eriksson; Ingiäld Hafström; Maria Dahlin; Per Åmark; Bo Angelin; Mats Rudling

Book ID
116372645
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
454 KB
Volume
8
Category
Article
ISSN
1550-4131

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The Circulating Metabolic Regulator FGF21 Is Induced by Prolonged Fasting and PPARα Activation in Man
✍ Cecilia Gälman; Tomas Lundåsen; Alexei Kharitonenkov; Holly A. Bina; Mats Erikss 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 454 KB

FGF21 is a critical metabolic regulator, pivotal for fasting adaptation and directly regulated by PPARalpha in rodents. However, the physiological role of FGF21 in man is not yet defined and was investigated in our study. Serum FGF21 varied 250-fold among 76 healthy individuals and did not relate to