Cytotoxic effects of glutathione synthes
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Robert T. Dorr; James D. Liddil; Michelle J. Soble
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Article
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1986
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Springer US
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English
⚖ 601 KB
The glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226