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Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells

✍ Scribed by Markus Duechler; Małgorzata Stańczyk; Małgorzata Czyż; Maciej Stępnik


Publisher
Springer
Year
2007
Tongue
English
Weight
733 KB
Volume
61
Category
Article
ISSN
0344-5704

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The glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226