Potentiating effect of distant sites in non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain
โ Scribed by Ya-Qiu Long; Ribo Guo; Juliet H Luo; Dajun Yang; Peter P Roller
- Book ID
- 116287089
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 160 KB
- Volume
- 310
- Category
- Article
- ISSN
- 0006-291X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Grb7 is a member of the Grb7 family of proteins, which also includes Grb10 and Grb14. All three proteins have been found to be overexpressed in certain cancers and cancer cell lines. In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20โ30% of breast
Srcโhomology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7โ18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein,