Development of non-phosphorylated cyclic thioether peptide binding to the Grb2-SH2 domain
โ Scribed by Feng-Di T. Lung; C. Richter King; Peter P. Roller
- Book ID
- 110268119
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 53 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1573-3149
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Srcโhomology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7โ18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein,