Global optimization of conformational constraint on non-phosphorylated cyclic peptide antagonists of the Grb2-SH2 domain
โ Scribed by Ya-Qiu Long; Feng-Di T. Lung; Peter P. Roller
- Book ID
- 108479382
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 246 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0968-0896
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Srcโhomology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7โ18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein,