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Conformation of an Shc-derived phosphotyrosine-containing peptide complexed with the Grb2 SH2 domain

✍ Scribed by Kenji Ogura; Shigeo Tsuchiya; Hiroaki Terasawa; Satoru Yuzawa; Hideki Hatanaka; Valsan Mandiyan; Joseph Schlessinger; Fuyuhiko Inagaki


Book ID
110369211
Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
199 KB
Volume
10
Category
Article
ISSN
0925-2738

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The 68 kDa Src substrate associated during mitosis (Sam68) is an RNA binding protein with Src homology (SH) 2 and 3 domain binding sites. We have recently found that Sam68 is a substrate of the insulin receptor (IR) that translocates from the nucleus to the cytoplasm and that Tyr-phosphorylated Sam6