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Use of SPR to Study the Interaction of G7-18NATE Peptide with the Grb7-SH2 Domain

โœ Scribed by Menachem J. Gunzburg; Nigus D. Ambaye; Jack T. Hertzog; Mark P. Del Borgo; Stephanie C. Pero; David N. Krag; Matthew C. J. Wilce; Marie-Isabel Aguilar; Patrick Perlmutter; Jacqueline A. Wilce

Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
395 KB
Volume
16
Category
Article
ISSN
1573-3149

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Srcโ€homology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7โ€18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein,

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## Abstract Grb7 is a member of the Grb7 family of proteins, which also includes Grb10 and Grb14. All three proteins have been found to be overexpressed in certain cancers and cancer cell lines. In particular, Grb7 (along with the receptor tyrosine kinase erbB2) is overexpressed in 20โ€“30% of breast