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Uptake of a cell permeable G7-18NATE construct into cells and binding with the Grb7-SH2 domain

✍ Scribed by Nigus D. Ambaye; Reece C. C. Lim; Daniel J. Clayton; Menachem J. Gunzburg; John T. Price; Stephanie C. Pero; David N. Krag; Matthew C. J. Wilce; Marie-Isabel Aguilar; Patrick Perlmutter; Jacqueline A. Wilce

Publisher: Wiley (John Wiley & Sons)
Year: 2011
Tongue: English
Weight: 321 KB
Volume: 96
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.21403

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Src‐homology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7‐18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein,