Potentiated glucose deprivation-induced death of astrocytes after induction of iNOS

✍ Scribed by Jung-Jin Choi; Won-Ki Kim

• Book ID: 101246026
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 141 KB
• Volume: 54
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/(sici)1097-4547(19981215)54:6<870::aid-jnr15>3.0.co;2-3

✦ Synopsis

Astrocytes play an essential role in the maintenance of normal neuronal function. Here we report that pretreatment of interferon-␥ (IFN-␥) and lipopolysaccharides (LPS) made murine astrocytes highly vulnerable to glucose deprivation-induced death. Neither 12-hr glucose deprivation nor 2-day treatment with IFN-␥ (100 U/ml) and LPS (1 g/ml) altered the viability of astrocytes. However, significant death of IFN-␥/LPStreated astrocytes was observed after 4-hr glucose deprivation. This augmented death was mimicked by the nitric oxide releasing reagent 3-morpholinosydnonimine and was in part prevented by the nitric oxide synthase inhibitor N G -nitroarginine. The data indicate that immunostimulated astrocytes can undergo suicidal death during glucose deprivation through the expression of inducible nitric oxide synthase.