Glucocorticoids exacerbate peroxynitrite mediated potentiation of glucose deprivation-induced death of rat primary astrocytes
โ Scribed by Chan Young Shin; Ji-Woong Choi; Eun Sook Jang; Jong Hoon Ryu; Won-Ki Kim; Hyoung-Chun Kim; Kwang Ho Ko
- Book ID
- 113997709
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 820 KB
- Volume
- 923
- Category
- Article
- ISSN
- 0006-8993
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Astrocytes play an essential role in the maintenance of normal neuronal function. Here we report that pretreatment of interferon-โฅ (IFN-โฅ) and lipopolysaccharides (LPS) made murine astrocytes highly vulnerable to glucose deprivation-induced death. Neither 12-hr glucose deprivation nor 2-day treatmen
## Abstract Astrocytes, the most abundant glial cell population in the central nervous system (CNS), play physiological roles in neuronal activities. Oxidative insult induced by the injury to the CNS causes neural cell death through extrinsic and intrinsic pathways. This study reports that reactive