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Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans

✍ Scribed by Durandy, Anne; Cantaert, Tineke; Kracker, Sven; Meffre, Eric

Book ID
120554685
Publisher
Informa plc
Year
2013
Tongue
English
Weight
462 KB
Volume
46
Category
Article
ISSN
0891-6934

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## Abstract Activation‐induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B‐cell malignancies. Notably, we found that the transgenic mice overexpressing AID deve