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Characterization of immunoglobulin mutations in humans with activation-induced cytidine deaminase deficiency

✍ Scribed by Nancy S Longo, Colleen Satorius, Anne Durandy…


Book ID
120706512
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
148 KB
Volume
9
Category
Article
ISSN
1478-6354

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## Abstract Activation‐induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B‐cell malignancies. Notably, we found that the transgenic mice overexpressing AID deve