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Glucocorticoid inhibition of activation-induced cytidine deaminase expression in human B lymphocytes

✍ Scribed by Benko, Ann L.; Olsen, Nancy J.; Kovacs, William J.

Book ID
125475457
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
777 KB
Volume
382
Category
Article
ISSN
0303-7207

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## Abstract Activation‐induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B‐cell malignancies. Notably, we found that the transgenic mice overexpressing AID deve