Potential Purine Antagonists. II. Synthesis of Some 7- and 5,7-Substituted Pyrazolo[4,3-d]pyrimidines 1
โ Scribed by Robins, Roland K.; Furcht, Frederick W.; Grauer, Alan D.; Jones, Jesse W.
- Book ID
- 120313203
- Publisher
- American Chemical Society
- Year
- 1956
- Tongue
- English
- Weight
- 617 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
Novel 2,3-substituted-2,4-dihydro-pyrazolo[4,3-d] pyrimidine-5,7-diones were successfully synthesized with moderate to good yields using a new synthetic approach. The structures of the regio-isomers in this series were determined by single crystal X-ray analysis and NMR spectra.
## Abstract Pyrazoloโ[3,4โ__d__]pyrimidineโ4,6โdiones **5** and pyrazolo[4,3โ__d__]pyrimidineโ5,7โdiones **7** were synthesized by Curtius rearrangement of pyrazolic monoโesters **2** and **3** followed by heteroโcyclization __via__ the ureas derivatives **4** and **6** under alkaline conditions.