Potential psychotomimetics. 2-Amino-1,2,3,4-tetrahydronaphthalene analogs
โ Scribed by Barfknecht, C. F.; Nichols, D. E.; Rusterholz, D. B.; Long, J. P.; Engelbrecht, J. A.; Beaton, J. M.; Bradley, R. J.; Dyer, D. C.
- Book ID
- 120635626
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 604 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
A novel asymmetric route to 2-amino-1,2,3,4-tetrahydronaphthalenes has been demonstrated starting from phthalimidovinylglycinol (PVG). Functionalisation of PVG via Heck reaction, olefin hydrogenation and cyclisation provides the title products.
## Abstract Enantiomerically pure __N__โprotected __cis__โ4โaminochromanโ3โol (key precursor in the synthesis of novel HIV secondโgeneration protease inhibitors), its __trans__ isomer and both __cis__โ and __trans__โ1โaminoโ1,2,3,4โtetrahydronaphthalenโ2โol, useful chiral catalysts in organic synth