## Abstract 2‐Amino‐1,2,3,4‐tetrahydronaphthalene‐6,7‐diol (**2**; 6,7‐ADTN) was synthesized starting from naphthalene‐2,3‐diol in seven steps and with an overall yield of 44%. Methylation of naphthalene‐2,3‐diol with dimethyl sulfate, followed by __Friedel____Crafts__ acylation with AcCl, gave 2‐
[3H]2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalen (ADTN)
✍ Scribed by Yvonne Clement-Cormier; Charles E. Smith
- Publisher
- Springer
- Year
- 1980
- Tongue
- English
- Weight
- 624 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0364-3190
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📜 SIMILAR VOLUMES
## Abstract Racemic 2‐amino‐1,2,3,4‐tetrahydronaphthalene‐5,6‐diol (5,6‐ADTN; **4**) was synthesized from 5,6‐dimethoxynaphthalene‐2‐carboxylic acid (**14**) in four steps (60% overall yield; __Scheme__). The crucial steps of the synthesis are __Birch__ reduction of **14** to the valuable synthon *
A new high yield synthesis of a potent dopamine agonist, 2-amino-6-7\_dihydroxytetrahydronaphthalene, is described utilizing a new annulation sequence.
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