Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'-monophosphate (DlvlrddUMP) (la) was synthesized as a potential membrane-permeable prodrug of ddUMP (3). Unlike the bis(pivaloyloxymethyl) analog, I b, la was completely resistant to degradation by plasma enzymes -a property that should enh
Potential prodrugs of phenelzine: N2-acetylphenelzine and N2-ethoxycarbonylphenelzine
β Scribed by Terry J. Danielson; Ronald T. Coutts; Glen B. Baker; Man C. Chan
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 231 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0022-3549
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A number of 2-N-alkylamino-or 2-N-phenylamino-, 2-N,N-RCH 2 CΟ΅CLi, or the lithiated allene, tBuCH=C=CHLi, and isothiocyanate, RΠN=C=S, in tetrahydrofuran and subse-dialkylamino-, and 2-N-alkyl-N-phenylaminothiophenes have been prepared in good yields by adding a solution of quently hydrolyzing the r