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One-Pot Syntheses of 2-N-Alkylamino-, 2-N-Phenylamino-, 2-N, N-Dialkylamino-, and 2-N-Alkyl-N-phenylaminothiophenes

✍ Scribed by Ol'ga A. Tarasova; Ludmila V. Klyba; Vladimir Yu. Vvedensky; Nina A. Nedolya; Boris A. Trofimov; Lambert Brandsma; Hermann D. Verkruijsse


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
353 KB
Volume
1998
Category
Article
ISSN
1434-193X

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✦ Synopsis


A number of 2-N-alkylamino-or 2-N-phenylamino-, 2-N,N-RCH 2 CϡCLi, or the lithiated allene, tBuCH=C=CHLi, and isothiocyanate, RЈN=C=S, in tetrahydrofuran and subse-dialkylamino-, and 2-N-alkyl-N-phenylaminothiophenes have been prepared in good yields by adding a solution of quently hydrolyzing the reaction mixture or quenching it with methyl iodide. tert-butylalcohol and potassium tert-butoxide in dimethylsulfoxide to a solution of the adduct from a lithiated 1-alkyne, Scheme 1


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