Bis(N,N-dimethylcarbamoyloxymethyl) 2′, 3′-dideoxyuridine 5′-monophosphate (DM2-ddUMP): A potential ddUMP prodrug

✍ Scribed by Saeed R. Khan; David Farquhar

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 197 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)02446-0

✦ Synopsis

Bis(N,N-dimethylcarbamoyloxymethyl) 2', 3'-dideoxyuridine 5'-monophosphate (DlvlrddUMP) (la) was synthesized as a potential membrane-permeable prodrug of ddUMP (3). Unlike the bis(pivaloyloxymethyl) analog, I b, la was completely resistant to degradation by plasma enzymes -a property that should enhance its bioavailability.