Potential inhibitors of protein biosynthesis
β Scribed by Hite, G.; Grollman, A. P.; Rosen, S.
- Book ID
- 126191927
- Publisher
- American Chemical Society
- Year
- 1971
- Tongue
- English
- Weight
- 364 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0022-2623
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A synthesis of ceramide analogs 6 and 7 is reported here starting from L-cysteine. Alkylation of 2 and subsequent reduction of the intermediate formed ketone 3 afforded the diitereomeric alcohols 4. Deprotection and acylation of 4 lead to the desired product 6 which is converted to the sulfonium sal
Antibiotic 1063-Z isolated from culture fluids of Streptoverticillium mobaraense was identified as pulvomycin. Pulvomycin was observed to inhibit protein biosynthesis in growing cells of Bacillus brevis. The poly(U)-directed poly(Phe) synthesis in cell-free systems of Bacillus brevis and Escherichia