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Potential Antitumor Agents, XIV. 1,8-Disubstituted Anthraquinones

✍ Scribed by Aldo Andreani; Mirella Rambaldi; Daniela Bonazzi; Giovanna Lelli; Lucedio Greci; Rosaria Bossa; Iraklis Galatulas


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
287 KB
Volume
318
Category
Article
ISSN
0365-6233

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Benzimidazo[1,2-c]quinazoline dimers as
✍ Miguel F. BraΓ±a; MarΓ­a JesΓΊs PΓ©rez de Vega; Denise Perron; Donna Conlon; Peter F πŸ“‚ Article πŸ“… 1997 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 451 KB πŸ‘ 1 views

## Abstract The 6‐substituted benzimidazo[1,2‐__c__]quinazoline 1 is a lead structure from our DNA intercalator program and is cytotoxic to the human colon cancer tumor line HT‐29 with an inhibitory concentration 50, IC~50~ of 4.00 ΞΌ__M__. In order to try and improve the limited cytotoxicity of thi