Benzimidazo[1,2-c]quinazoline dimers as
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Miguel F. BraΓ±a; MarΓa JesΓΊs PΓ©rez de Vega; Denise Perron; Donna Conlon; Peter F
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Article
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1997
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Journal of Heterocyclic Chemistry
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English
β 451 KB
π 1 views
## Abstract The 6βsubstituted benzimidazo[1,2β__c__]quinazoline 1 is a lead structure from our DNA intercalator program and is cytotoxic to the human colon cancer tumor line HTβ29 with an inhibitory concentration 50, IC~50~ of 4.00 ΞΌ__M__. In order to try and improve the limited cytotoxicity of thi