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Potential Anticancer Agents. 1 LXX. Some Simple Derivatives of the Actinomycins

โœ Scribed by WEINSTEIN, BORIS; CREWS, OSBORNE P.; LEAFFER, MORRIS A.; BAKER, B. R.; GOODMAN, LEON

Book ID
125996127
Publisher
American Chemical Society
Year
1962
Tongue
English
Weight
934 KB
Volume
27
Category
Article
ISSN
0022-3263

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The synthesis of anthraquinone derivativ
The synthesis of anthraquinone derivatives as potential anticancer agents
โœ Ping Ge; Richard A. Russell ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 465 KB

The simple anthracycline analogues 3a-e were synthesized as potential anticancer agents. Anodic oxidation of the phenol derivative 4, phthalide anion annelation ofp-quinone monoacetals 5 and selective attachment of the side chain were the three key steps towards these target compounds.