Potent interactions between NE and 5-HT systems
β Scribed by G. Aston-Jones
- Book ID
- 118856830
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 161 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-3223
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Using an in vivo electrophysiological paradigm, venlafaxine and paroxetine displayed similar potency for suppressing the firing activity of dorsal raphe 5-HT neurons (ED 50 : 233 and 211 Β΅g/kg i.v., respectively), while venlafaxine was three times less potent than desipramine (ED 50 : 727 and 241 Β΅g