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Interaction between 5-HT and NE in human anxiety

โœ Scribed by A.W. Goddard


Book ID
118856827
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
319 KB
Volume
35
Category
Article
ISSN
0006-3223

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Using an in vivo electrophysiological paradigm, venlafaxine and paroxetine displayed similar potency for suppressing the firing activity of dorsal raphe 5-HT neurons (ED 50 : 233 and 211 ยตg/kg i.v., respectively), while venlafaxine was three times less potent than desipramine (ED 50 : 727 and 241 ยตg