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Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies

✍ Scribed by Vanda Bartoňová; Vlastimil Král; Irena Sieglová; Jiří Brynda; Milan Fábry; Magdalena Hořejší; Milan Kožíšek; Klára Grantz Šašková; Jan Konvalinka; Juraj Sedláček; Pavlína Řezáčová

Book ID
113457670
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
247 KB
Volume
78
Category
Article
ISSN
0166-3542

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Inhibition of HIV protease by monoclonal
Inhibition of HIV protease by monoclonal antibodies
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## Abstract The protease of HIV plays a critical role in the maturation of the infectious particles of the virus. The enzyme has therefore been extensively studied with the objective of developing therapeutics that inhibit viral proliferation. We have produced monoclonal antibodies specific for the