Geraniol, an abundantly available naturally occurring allylic alcohol, has been used as a starting material to prepare a series of 6-[a-(3 0 -aryl-3 0 -hydroxypropyl)vinyl]-1,2,4-trioxanes. Some of these novel trioxanes have shown very promising antimalarial activity against multi-drug resistant Pla
Potent Antimalarial 1,2,4-Trioxanes through Perhydrolysis of Epoxides
โ Scribed by Hao, Hong-Dong; Wittlin, Sergio; Wu, Yikang
- Book ID
- 121274734
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 553 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0947-6539
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๐ SIMILAR VOLUMES
The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensiti
Oxidative cleavage of alkenyl esters and ethers using Et$iOOOH was found to be easier than oxidative cleavage of hydrocarbon alkenes, and Et3SiOOOH was successfully applied to very short syntheses of new, simple, and potent antimalarial trioxanes 6 and 8. We have reported recently that triethylsily