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Synthesis and Antimalarial Activity of 3,3-Spiroanellated 5,6-Disubstituted 1,2,4-Trioxanes

✍ Scribed by Maurya, Ranjani; Soni, Awakash; Anand, Devireddy; Ravi, Makthala; Raju, Kanumuri S. R.; Taneja, Isha; Naikade, Niraj K.; Puri, S. K.; Wahajuddin, ; Kanojiya, Sanjeev; Yadav, Prem P.


Book ID
118229672
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
592 KB
Volume
4
Category
Article
ISSN
1948-5875

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The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensiti