Geraniol-derived 1,2,4-Trioxanes with potent in-vivo antimalarial activity

✍ Scribed by Chandan Singh; Nitin Gupta; Sunil K Puri

• Book ID: 104364086
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 170 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00782-0

✦ Synopsis

Geraniol, an abundantly available naturally occurring allylic alcohol, has been used as a starting material to prepare a series of 6-[a-(3 0 -aryl-3 0 -hydroxypropyl)vinyl]-1,2,4-trioxanes. Some of these novel trioxanes have shown very promising antimalarial activity against multi-drug resistant Plasmodium yoelii in mice by both intramuscular (im) and oral routes.