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New Orally Active Spiro 1,2,4-Trioxanes with High Antimalarial Potency.

โœ Scribed by Chandan Singh; Heetika Malik; Sunil K. Puri

Publisher
John Wiley and Sons
Year
2006
Weight
17 KB
Volume
37
Category
Article
ISSN
0931-7597

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The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensiti