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Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base

✍ Scribed by McGuigan, Christopher; Yarnold, Christopher J.; Jones, Garry; Velázquez, Sonsoles; Barucki, Hubert; Brancale, Andrea; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan


Book ID
121428997
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
73 KB
Volume
42
Category
Article
ISSN
0022-2623

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✍ Erik De Clercq 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB 👁 1 views

## Abstract The bicyclic furo[2,3‐__d__]pyrimidine nucleoside analogues represent an entirely new class of fused furopyrimidine derivatives with unprecedented selectivity for varicella‐zoster virus (VZV). From extensive structure‐activity relationship (SAR) studies, the 6‐(__p__‐alkylphenyl)substit