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Metabolic and Pharmacological Characteristics of the Bicyclic Nucleoside Analogues (BCNAs) as Highly Selective Inhibitors of Varicella—Zoster Virus (VZV)

✍ Scribed by R. Sienaert; L. Naesens; A. Brancale; A. Carangio; G. Andrei; R. Snoeck; A. Van Kuilenburg; E. De Clercq; C. McGuigan; J. Balzarini

Publisher
John Wiley and Sons
Year
2004
Weight
56 KB
Volume
35
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

📜 SIMILAR VOLUMES

Highly potent and selective inhibition o
Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues
✍ Erik De Clercq 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB 👁 1 views

## Abstract The bicyclic furo[2,3‐__d__]pyrimidine nucleoside analogues represent an entirely new class of fused furopyrimidine derivatives with unprecedented selectivity for varicella‐zoster virus (VZV). From extensive structure‐activity relationship (SAR) studies, the 6‐(__p__‐alkylphenyl)substit