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ChemInform Abstract: 2′-Fluorosugar Analogues of the Highly Potent anti-Varicella-Zoster Virus Bicyclic Nucleoside Analogue (BCNA) Cf 1743.

✍ Scribed by Christopher McGuigan; Marco Derudas; Maurizio Quintiliani; Graciela Andrei; Robert Snoeck; Geoffrey Henson; Jan Balzarini


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
41
Category
Article
ISSN
0931-7597

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## Abstract The bicyclic furo[2,3‐__d__]pyrimidine nucleoside analogues represent an entirely new class of fused furopyrimidine derivatives with unprecedented selectivity for varicella‐zoster virus (VZV). From extensive structure‐activity relationship (SAR) studies, the 6‐(__p__‐alkylphenyl)substit