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Highly Potent and Selective Inhibition of Varicella-Zoster Virus by Bicyclic Furopyrimidine Nucleosides Bearing an Aryl Side Chain

✍ Scribed by McGuigan, Christopher; Barucki, Hubert; Blewett, Sally; Carangio, Antonella; Erichsen, Jonathan T.; Andrei, Graciela; Snoeck, Robert; De Clercq, Erik; Balzarini, Jan


Book ID
127160239
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
69 KB
Volume
43
Category
Article
ISSN
0022-2623

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Highly potent and selective inhibition o
✍ Erik De Clercq 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 343 KB 👁 1 views

## Abstract The bicyclic furo[2,3‐__d__]pyrimidine nucleoside analogues represent an entirely new class of fused furopyrimidine derivatives with unprecedented selectivity for varicella‐zoster virus (VZV). From extensive structure‐activity relationship (SAR) studies, the 6‐(__p__‐alkylphenyl)substit