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Posttranslational Modifications of Self-Antigens

โœ Scribed by HESTER A. DOYLE; MARK J. MAMULA

Book ID
111478521
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
549 KB
Volume
1050
Category
Article
ISSN
0890-6564

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Alterations in amino acid sequence can generate neo-epitopes from self proteins, causing autoaggressive immune attack. There is a range of possible post-translational modifications (PTMs) of mammalian proteins that can allow immune recognition of neo-self epitopes. These effects can vary from overt