Postoperative fluctuations of tissue plasminogen activator (t-PA) in aqueous humor of pseudophakes
β Scribed by Yoshitomi, Fumiaki; Utsumi, Eiichiro; Hayashi, Masayasu; Futenma, Minorti; Yamada, Ritsuko; Yamada, Seiichi
- Book ID
- 122301243
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 784 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0886-3350
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A protease-deficient strain of Aspergillus niger has been used as a host for the production of human tissue plasminogen activator (t-PA). In defined medium, up to 0.07 mg t-PA (g biomass)(-1) was produced in batch and fed-batch cultures and production was increased two- to threefold in two-phase bat
Full-length tissue-type plasminogen activator (t-PA) cDNA served to construct deletion mutants within the N-terminal "heavy" (H)-chain of the t-PA molecule. The H-chain cDNA consists of an array of structural domains homologous to domains present on other plasma proteins ("finger, " "epidermal growt