Post-translational modifications: A shift for the O-GlcNAc paradigm
โ Scribed by Kohler, Jennifer J
- Book ID
- 109913416
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 194 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1552-4450
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๐ SIMILAR VOLUMES
N-Acetylglucosamine O-linked to serines and threonines of cytosolic and nuclear proteins (O-GlcNAc) is an abundant reversible post-translational modification found in all higher eukaryotes. Evidence for functional regulation of proteins by this dynamic saccharide is rapidly accumulating. Deletion of
O-GlcNAc is an ubiquitous post-translational protein modification consisting of a single Nacetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified pr