O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar

Diverse regulation of protein function b

Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification

✍ Keith Vosseller; Kaoru Sakabe; Lance Wells; Gerald W Hart 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 156 KB

N-Acetylglucosamine O-linked to serines and threonines of cytosolic and nuclear proteins (O-GlcNAc) is an abundant reversible post-translational modification found in all higher eukaryotes. Evidence for functional regulation of proteins by this dynamic saccharide is rapidly accumulating. Deletion of