O-GlcNAc cycling: How a single sugar post-translational modification is changing the Way We think about signaling networks
✍ Scribed by Chad Slawson; Michael P. Housley; Gerald W. Hart
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 355 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0730-2312
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✦ Synopsis
O-GlcNAc is an ubiquitous post-translational protein modification consisting of a single Nacetlyglucosamine moiety linked to serine or threonine residues on nuclear and cytoplasmic proteins. Recent work has begun to uncover the functional roles of O-GlcNAc in cellular processes. O-GlcNAc modified proteins are involved in sensing the nutrient status of the surrounding cellular environment and adjusting the activity of cellular proteins accordingly. O-GlcNAc regulates cellular responses to hormones such as insulin, initiates a protective response to stress, modulates a cell's capacity to grow and divide, and regulates gene transcription. This review will focus on recent work involving O-GlcNAc in sensing the environment and regulating signaling cascades.