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Possible mechanism of action of deprenyl in parkinsonism

✍ Scribed by Paterson, I.A; Juorio, A.V; Boulton, A.A


Book ID
122488688
Publisher
The Lancet
Year
1990
Tongue
English
Weight
157 KB
Volume
336
Category
Article
ISSN
0140-6736

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Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) neurons by inhibiting monoamine oxidase B necessary to mediate the conversion of MPTP to MPP +, its active metabolite, in astro